A splash shield for containing contaminated fluids from a wound and a method of use are disclosed. The shield is a transparent dome-shaped body made from a plastic film. The shield can be pierced by a sharp medical instrument, such as a hypodermic syringe or scalpel, and the wound cleansing or draining operation takes place under the shield as it is held against the patient. The shield is deformed by hand to conform to the wound site. The shield can also be hand held above and spaced from the wound site while the cleansing or draining operation takes place, to intercept and provide protection from splashed or squirted fluids. The shield is provided in single use, disposable form.